Randomised Phase II, Cetuximab in Combination With 5FU and Cisplatin or Carboplatin Versus Cetuximab in Combination With Paclitaxel and Carboplatin for Treatment of Patients With Metastatic Squamous Cell Carcinoma of the Head and Neck

• Status: Unknown status
• Trial end date: 2015-11-01

Summary

Primary To investigate in patients with relapsed or metastatic squamous cell carcinoma of the head and neck whether progression free survival (PFS) in the arm with cetuximab, paclitaxel and carboplatin based chemotherapy is not markedly worse than PFS in the arm with cetuximab and 5-FU, cisplatin or carboplatin based chemotherapy.

Secondary

To compare in patients with relapsed or metastatic squamous cell carcinoma of the head and neck the following study variables between both treatment arms:

• Best overall response

• Duration of response

• Time to treatment failure

• Overall survival

• Safety

• Phase: Phase 2

Details

• Lead Sponsor: Karolinska University Hospital
• Treatments: Albumin-Bound Paclitaxel; Carboplatin; Cetuximab; Cisplatin; Paclitaxel