Overview

Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT)

Status:
Completed

Trial end date:
2015-08-01

Target enrollment:

Participant gender:

Summary

CACTUS-PTS is a randomized, placebo-controlled, double-blind study which aims primarily to determine the effectiveness of a 6 week course of therapeutic-dose LMWH (nadroparine) injections vs. placebo in patients with a first symptomatic isolated distal (calf) deep-vein thrombosis (IDDVT), as measured by rate of proximal DVT and symptomatic PE at 6 weeks. Additionally, the study aims to determine if the 6 week course of treatment with therapeutic-dose LMWH (nadroparine) injections, compared to placebo, decreases the frequency of post-thrombotic syndrome (PTS) at 1 year.

Phase:

Phase 3

Details

Lead Sponsor:

University Hospital, Geneva

Collaborators:

Canadian Institutes of Health Research (CIHR)
Lady Davis Institute
Ministry of Health, France
Swiss National Science Foundation

Treatments:

Calcium
Nadroparin