Overview

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

Status:
Terminated

Trial end date:
2020-12-02

Target enrollment:

Participant gender:

Summary

The purpose of the present study is to determine whether treatment of hemodynamically significant patent ductus arteriosus with a combined therapy of intravenous Ibuprofen and oral acetaminophen has higher success rate in closing the ductus arteriosus than a standard treatment strategy of using intravenous ibuprofen alone among preterm infants.

Phase:

Phase 2

Details

Lead Sponsor:

University of South Alabama

Treatments:

Acetaminophen
Ibuprofen