Randomized HaploCord Blood Transplantation vs. Double Umbilical Cord Blood Transplantation for Hematologic Malignancies
Status:
Terminated
Trial end date:
2015-04-29
Target enrollment:
Participant gender:
Summary
The purpose of this study is compare the efficacy of haplo-cord transplant (investigational
arm) with that of a more commonly used procedure in which only the cells contained in one or
two umbilical cords are infused (standard arm).
We hypothesize that reduced intensity conditioning and haplo-cord transplant results in fast
engraftment of neutrophils and platelets, low incidences of acute and chronic graft versus
host disease, low frequency of delayed opportunistic infections, reduced transfusion
requirements, shortened length of hospital stay and promising long term outcomes. We also
hypothesize that umbilical cord blood selection can prioritize matching and better matched
donors can be identified rapidly for most subjects.