Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthesia practice in the 21st century is increasingly outcomes-oriented and evidence-based, but there remain significant gaps in our knowledge, even for commonly-encountered clinical situations. Currently, the two most commonly used drugs used for maintenance of anesthesia in cardiac surgical patients are isoflurane and sevoflurane. There is a belief among many cardiac anesthesiologists that sevoflurane is a better cardiac anesthetic than isoflurane, but there is very little data to support this notion. In fact, very little is known about their comparative effects on important patient outcomes because there has not been a large head-to-head prospective randomized clinical trial. This project will supply the data necessary to critically compare the two anesthetics.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Treatments: Anesthetics; Isoflurane; Sevoflurane

Criteria

Inclusion Criteria:

• Patients must be 18 years or over (There is no upper age limit to enrollment)

• Eligible procedures are: CABG on-pump or off-pump, single valve repair/replacement, or CABG/single valve combined procedures

Exclusion Criteria:

• Cardiac surgeries that are not one of the included cases

• Planned extubation in the operating room

• Patients refusing blood products (vis à vis blood sampling)

• Pregnant patients

• Malignant hyperthermia or documented/stated allergy to potent volatile anesthetic agents