Randomized, Placebo-controlled Study to Evaluate Effects of E5555 on Renal Function Parameters and OCT2 Activity
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This is a drug-drug interaction study to evaluate the effects of steady-state exposure of
E5555 and its main metabolites on the pharmacokinetics (PK) of metformin, an organic cation
transporter-2 (OCT2) substrate. In addition, the study will also investigate the effects of
E5555 on several renal function parameters.