Randomized Study of Letrozole and Trilostane for Medical Abortion
Status:
Terminated
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and
estrogen levels fall sharply at this time. During medical abortion the endometrial shedding
is sometimes ineffective causing an incomplete abortion which may cause prolonged bleeding or
require surgical intervention. In medical abortion a progesterone antagonist is used as
treatment but the estrogen levels are not targeted. The investigators wish to explore whether
addition of letrozole or trilostane which target estrogen levels can lead to a more effective
shedding of the endometrial lining.