Randomized Study of Testosterone and Progressive Resistance Exercise in Men With Burn Injury
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Determine whether testosterone normalization ameliorates muscle protein
hypercatabolism by increasing net protein synthesis in men with burn injury.
II. Determine whether the effectiveness of testosterone is enhanced by stimulation of inward
amino acid transport as a consequence of hyperaminoacidemia in these men.
III. Determine whether testosterone normalization during hospitalization minimizes the need
for rehabilitation by increasing net protein synthesis and preserving skeletal muscle in
these men.
IV. Determine whether testosterone normalization after hospital discharge and throughout
convalescence increases muscle strength and lean body mass after burn injury by increasing
net protein synthesis.
V. Determine whether testosterone combined with progressive resistance exercise during
convalescence confers added benefits on muscle protein synthesis, and in turn, lean body mass
and muscle strength in these patients.