Randomized Trial Comparing Sirolimus and Tacrolimus Versus Cyclosporine and Methotrexate as Graft-versus-host Disease (GVHD) Prophylaxis After Allogeneic Stem Cell Transplantation

• Status: Completed
• Trial end date: 2015-04-01

Summary

To evaluate if rapamune + tacrolimus immunosuppressive prophylaxis is better than the established therapy using cyclosporine and methotrexate, a Nordic prospective multicenter randomized study will be performed. Patients will be randomized to treatment with rapamune combined with tacrolimus, or the established therapy using cyclosporine and methotrexate.

• Phase: Phase 3

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Cyclosporine; Cyclosporins; Everolimus; Methotrexate; Sirolimus; Tacrolimus