Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Patients who are undergoing colonoscopy and are not adequately sedated after initial standard
sedation with midazolam 5 mg and fentanyl 100 mcg will be randomly assigned to receive
diphenhydramine vs. continued midazolam, and their level of sedation will be assessed. Our
hypothesis is that diphenhydramine will provide better sedation than continued administration
of midazolam during colonoscopy in patients not achieving adequate sedation with standard
doses of midazolam plus fentanyl.