Randomized Trial of Radiation Therapy With or Without Chemotherapy for Endometrial Cancer
Status:
Active, not recruiting
Trial end date:
2027-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells.
Giving chemotherapy and radiation therapy after surgery may kill any tumor cells that remain
after surgery. It is not yet known whether giving chemotherapy together with radiation
therapy is more effective than giving radiation therapy alone in treating endometrial cancer.
PURPOSE: This randomized phase III trial is studying chemotherapy and radiation therapy to
see how well they work compared with radiation therapy alone in treating patients with
high-risk, stage I, stage II, or stage III endometrial cancer.
Phase:
Phase 3
Details
Lead Sponsor:
Leiden University Medical Center
Collaborators:
Australia New Zealand Gynaecological Oncology Group Cancer Research UK Mario Negri Institute for Pharmacological Research NCIC Clinical Trials Group UNICANCER