Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the proposed study is to determine if pairing reactivation of a traumatic memory with a single administration of Rapamycin (e.g., Sirolimus) in men with combat-related Posttraumatic Stress Disorder leads to a reduction of the emotional strength of that particular traumatic memory.

The following hypotheses will be tested:

1. Traumatic memory reactivation paired with a single dose of Rapamycin will decrease objective measures of stress and self-report of stress during replay of the traumatic memory, relative to, subjects receiving placebo.

2. Pairing administration of Rapamycin with traumatic memory reactivation will decrease symptoms of Posttraumatic Stress Disorder one month and three months later, relative to patients receiving placebo.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Collaborator: North Texas Veterans Healthcare System
• Treatments: Everolimus; Sirolimus

Criteria

Inclusion Criteria:

• Male Veterans

• Diagnosis of Posttraumatic Stress Disorder related to combat

Exclusion Criteria:

• Hypersensitivity to Rapamycin

• Organic brain damage (including unresolved Traumatic Brain Injury sequela)

• Substance dependence in the last three months

• On any immunosuppressant therapy

• Prominent suicidal or homicidal features

• Medical conditions: systemic infections, congestive heart failure, renal failure, hepatic failure