Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
Status:
Completed
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
The purpose of the proposed study is to determine if pairing reactivation of a traumatic
memory with a single administration of Rapamycin (e.g., Sirolimus) in men with combat-related
Posttraumatic Stress Disorder leads to a reduction of the emotional strength of that
particular traumatic memory.
The following hypotheses will be tested:
1. Traumatic memory reactivation paired with a single dose of Rapamycin will decrease
objective measures of stress and self-report of stress during replay of the traumatic
memory, relative to, subjects receiving placebo.
2. Pairing administration of Rapamycin with traumatic memory reactivation will decrease
symptoms of Posttraumatic Stress Disorder one month and three months later, relative to
patients receiving placebo.