Rapid Sequence Induction: Succinyl Choline vs Rocuronium After Pretreatment With Dexmedetomidine

• Status: Enrolling by invitation
• Trial end date: 2021-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Background: Rapid sequence induction is a well-established anesthetic procedure used in trauma setting and patients with full stomach. Succinyl choline has the been the drug of choice, however, it carries potential risk and sometimes fatal outcome. Aim of the study: to compare rocuronium after pre-treatment with Dexmedetomidine, to succinyl choline in providing excellent intubating conditions. Material and method: Patients were randomly allocated to one of two groups, of 120 each. Control (SS) group, patients received pretreatment with 10 ml 0.9% saline over 10 minutes, and succinyl choline 1mg/ kg was on induction. Experimental (DR) group, received pretreatment with Dex 1 µg / kg in 10 ml 0.9% saline over 10 minutes and rocuronium 0.6 mg/kg on induction.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: South Valley University
• Treatments: Choline; Rocuronium; Succinylcholine

Criteria

Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) physical status I or II

2. scheduled for elective surgery of more than 60 minutes duration. -

Exclusion Criteria:

1. Mallampati score of III or IV

2. Neuromuscular disease

3. History of allergy to the studied drugs

4. Malignant hyperthermia

5. Patients taking anticonvulsants or aminoglycoside antibiotic

6. Hepatic dysfunction

7. Renal dysfunction

8. Cardiovascular dysfunction;

9. Electrolyte imbalance

10. Morbidly obese with a body mass index (BMI) more than 30 kg/m2

11. Pregnant or nursing mothers.