Rationale for New Topical Anthroponotic Cutaneous Leishmaniasis (ACL) Treatment in Kabul

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the randomized double blind trial with 134 patients presenting old world cutaneous leishmaniasis is:

• to evaluate the clinical efficacy of electro-thermo-cauterisation (ETC) followed by moist wound treatment versus ETC followed by moist wound treatment plus 0.05 % pharmaceutical chlorite that has been used in three European countries (Germany, Austria and Switzerland) in wound care management for more than 20 years;

• to judge whether early wound care management would present a viable improvement to the actual anti-parasitic treatments mostly neglecting the chronic wound problem and to evaluate its long-term effect on immunity through relapse control 6 months after wound healing.

• Phase: Phase 2/Phase 3

Details

• Lead Sponsor: Waisenmedizin e. V. Promoting Access to Essential Medicine
• Collaborators: German Medical Service (GMS) in Kabul; German Medical Service Kabul GMS non-profit Afghan NGO; Microbiology Institute Clinical Microbiology Immunology and Hygiene University Clinic of Erlangen Germany; University of Freiburg; Waisenmedzin eV PACEM non-profit German NGO

Criteria

Inclusion Criteria:

• at least one suspected lesion positive in Giemsa smear

Exclusion Criteria:

• patients previously treated for leishmania