Re-entry XR-NTX for Rural Individuals With Opioid Use Disorder

• Status: Recruiting
• Trial end date: 2022-03-31
• Target enrollment: 0
• Participant gender: All

Summary

The overall aim of this R34 proposal is to examine the feasibility, acceptability, and short-term outcomes associated with an innovative service delivery model to increase adherence to extended-release naltrexone (XR-NTX) during the transition from jail to the community for rural individuals with opioid use disorder (OUD). The significance of this study is grounded in the public health emergency associated with the opioid epidemic in rural Appalachia, the increased vulnerability of rural individuals with OUD, and the dearth of available and accessible evidence-based treatment in the region. This study has potential to make a significant contribution to the OUD treatment field by advancing knowledge on innovative service delivery models to increase access to evidence-based treatment to reduce the prevalence of opioid use disorders and related health disparities among hard-to-reach, high-risk, underserved populations.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Michele Staton; University of Kentucky

Criteria

Inclusion Criteria:

• Meets criteria for opioid use disorder

• Anticipated release date within 30 days

• Opioid free

• Not currently in methadone or buprenorphine trial

• No serious medical or psychiatric condition

• Willingness to enroll in the trial

Exclusion Criteria:

• Positive study pregnancy test

• Abnormal liver function tests (5X upper limits of normal)

• Chronic pain conditions that require opioid therapies

• Untreated medical or psychiatric disorder

• Suicidal ideation

• BMI > 40