Real-Time Image Guided Lymphatic Mapping and Nodal Targeting in Lung Cancer

• Status: Active, not recruiting
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this study is to determine if we can identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to remove this additional site that potentially contains tumor cells.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dana-Farber Cancer Institute
• Collaborators: Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Massachusetts General Hospital

Criteria

Inclusion Criteria:

• Suspected or histologically documented new non-small cell carcinoma that have agreed to undergo a thoracotomy for segmentectomy, lobectomy, bilobectomy or pneumonectomy as recommended by their thoracic surgeon for treatment

• Surgically resectable lung cancer

• N2 lymph nodes negative on PET scan or mediastinoscopy

• Age > or equal to 18 years of age

• Men, women of non-child bearing age or women with a negative pregnancy test

Exclusion Criteria:

• Patient does not want to undergo subsequent surgical resection

• Medical condition such as uncontrolled infection or cardiac disease that, i the opinion of the treating surgeon, makes resection unreasonably hazardous for the patient.

• T4 or N2 disease

• Pre-operative spirometry that suggests they cannot undergo resection of their primary tumor by segmentectomy, lobectomy, bilobectomy, or pneumonectomy

• Iodide or seafood allergy

• Pregnant or lactating women