Rebalancing the Serotonergic System in Cocaine Dependence
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
In the United States, 1.5 million people abuse cocaine leading to a host of negative health
and economic consequences, yet no FDA approved treatment exists. To develop effective
treatments, the following must be considered: 1) do potential medications ameliorate brain
disruptions associated with cocaine use? 2) are multiple, targeted treatments necessary? To
meet these goals, innovative multi-modal neuroimaging will be used to determine whether
rebalancing the serotonergic (5-HT) system reduces cocaine cue reactivity, impulsivity, and
normalizes related neurochemistry and brain connectivity.