Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain

• Status: Not yet recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this study is to document the feasibility and acceptability of an intervention consisting of pain neuroscience education and reconsolidation therapy with propranolol in adults suffering from chronic pain (chronic low back pain or fibromyalgia).

The secondary aim of the study is to estimate the effect size of the intervention on pain and function one month post-intervention, and to obtain data for sample-size calculation for a subsequent RCT.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Université de Sherbrooke
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• French speaking

• Suffering from [chronic low back pain OR fibromyalgia] for >6 months

• Average pain at least 4/10

• Central sensitization (assessed via a standardized physiotherapy evaluation and the Central Sensitization Inventory)

Exclusion Criteria:

• Health condition for which propranolol is contra-indicated

• Medication with which co-administration of propranolol is contra-indicated

• Severe or uncontrolled neurological/psychiatric condition (including post-traumatic stress disorder, substance abuse, suicidal ideation, etc.)

• Surgery of the lower-back in the last 3 years

• Litigation surrounding the painful condition