Rectal Misoprostol in Women Undergoing Myomectomy for Intraoperative Blood Loss: A Randomized Placebo-controlled Study

• Status: Completed
• Trial end date: 2018-04-30
• Target enrollment: 0
• Participant gender: Female

Summary

Comparison of efficacy of rectal misoprostol for reduction amount of blood loss in women undergoing myomectomy, both open and laparoscopic approach

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rajavithi Hospital
• Treatments: Misoprostol; Vitamin B 6

Criteria

Inclusion Criteria:

• Patient provisionally diagnosed with leiomyoma of uterus with less than 10 cm diameter

• Patient undergoing myomectomy, both open and laparoscopic approach

• Patient aged 25 - 50 years

• Patient able to give free and informed consent and who agrees to participate bu signing the consent form

• Patient able to speak and understand Thai

• Patient able to complete the questionnaire

Exclusion Criteria:

• Patient who was pathologically diagnosed apart from leiomyoma

• Patient with leiomyoma FIGO type 0

• Patient who has medical conditions that increase bleeding tendency, such as thrombocytopenia, coagulopathy, renal insufficiency, uncontrolled diabetes mellitus, taking antiplatelets or anticoagulants less than 7 days prior the surgery

• Patient who takes prostaglandin analogs and/or antagonists (NSAIDS) less than 7 days prior the surgery.

• Patient who may take higher risks of misoprostol adverse effect such as hypertension, ischemic heart disease, glaucoma, asthma

• Patient who had and allergic reaction to misoprostol or vitamin B6