Red Blood Cell ATP Release and Vascular Function in Humans

• Status: Completed
• Trial end date: 2018-10-05
• Target enrollment: 0
• Participant gender: All

Summary

Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults. The investigators are targeting a pathway within the red blood cell using fasudil hydrochloride to determine if both the release of ATP from red blood cells and blood flow responses to low oxygen (hypoxia) and exercise in older adults can be improved.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colorado State University
• Treatments: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Fasudil

Criteria

Inclusion Criteria:

• Healthy

• Sedentary to moderately active

• 18 to 30 years old for young subjects

• 60 to 80 years old for older subjects

Exclusion Criteria:

• Obesity (BMI ≥ 30 kg/m^2)

• Cardiovascular disease

• Metabolic disease

• Use of medications that can influence cardiovascular function

• Blood pressure greater than or equal to 140/90

• Smoker

• Use of hormone replacement therapy