Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
This is a Phase II pilot study to evaluate engraftment and toxicity of patients with
non-malignant diseases using a reduced intensity conditioning regimen in the setting of
allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be
acceptable as a stem cell source.
Recently, reduced intensity conditioning (RIC) regimens have been used for both adult
patients with leukemias and pediatric patients with non-malignant diseases. These regimens
are better tolerated, resulting in less transplant related morbidity and mortality. Stable
mixed chimerism, while insufficient for eradication of leukemias, may be sufficient to cure
patients with non-malignant diseases.