Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma
Status:
Terminated
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Photopheresis allows patient white blood cells to be treated with ultraviolet (UV)
light and drugs outside the body to inactivate T cells. Pentostatin may suppress the immune
system and reduce the chance of developing graft-versus-host disease (GVHD) following bone
marrow transplantation. Combining photopheresis with pentostatin and total-body irradiation
may be effective in killing cancer cells before bone marrow transplantation.
PURPOSE: This phase II trial is studying how well giving photophoresis together with
pentostatin and total-body irradiation as a reduced-intensity regimen before allogeneic bone
marrow transplantation works in treating patients with relapsed non-Hodgkin's or Hodgkin's
lymphoma.