Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery

• Status: Not yet recruiting
• Trial end date: 2025-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered. DHA has been proven to be effective although it comes with multiple risks related to organ hypoperfusion including kidney injury, stroke, and cardiac ischemia. Therefore, it may be potentially safer for patients to avoid deliberate hypotensive anesthesia if TXA alone adequately controls blood loss and provides adequate surgical site visualization.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Antihypertensive Agents; Tranexamic Acid

Criteria

Inclusion Criteria:

• Bimaxillary orthognathic surgery completed at UAB Highlands Hospital

Exclusion Criteria:

• History of hypertension or previously diagnosed cardiac problems

• Bleeding diathesis

• TXA medically contraindicated