Reducing Reconsolidation of Trauma Memories With Propranolol

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test whether propranolol is capable of reducing subsequent physiological trauma-related conditioned responses, as well as self-reported post-traumatic stress disorder (PTSD) symptoms.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Douglas Mental Health University Institute
• Collaborator: Canadian Institutes of Health Research (CIHR)
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Suffer from chronic PTSD for at least 6 consecutive months;

• Obtain a score of 33 or more on the Impact of Events Scale-Revised:

• For participants aged 40 years: accept to undergo an electrocardiogram assessment. The results of the electrocardiogram must be normal;

• Accept to not commence taking new medications on a regular basis during the study.

Exclusion Criteria:

• Hypotension;

• Cardiac rhythm below 55 beats per minute;

• Medical conditions that contraindicates the administration of propranolol;

• Previous adverse reaction to, or non-compliance with, beta-blockers;

• Current use of medication that may involve potentially dangerous interactions with propranolol;

• Any medication that can have an impact on cardiac rhythm;

• Women who are breast feeding;

• Past or present bipolar disorder or psychosis,

• Present substance abuse or dependence, suicidal ideation;

• Participating in psychotherapy other than support psychotherapy;

• An average score above 20 on the Dissociative Experience Scale.