Reducing the Abuse Liability of Prescription Opioids

• Status: Completed
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Opioid (commonly called narcotic) pain medicines are, after marijuana, the most commonly abused substances in the United States. Patients who take opioids for legitimate reasons may become addicted; for example, as many as 1 in 4 patients meet the criteria for current opioid dependence. It is very important that a way is found to provide pain relief while minimizing the addiction potential of these widely used pain medications.

The study aim to find out if the use of another type of medication given in addition to an opioid will reduce the addiction potential of the opioid.

The study is trying to find out if the ability of the opioid to relieve pain is changed when given with the other medication, and to see if the euphoric sensation or "liking" of the opioid pain medication is reduced when taken with the other medication.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center at San Antonio
• Treatments: Oxycodone; Risperidone; Ziprasidone

Criteria

Inclusion Criteria:

• Requirement of prior exposure to opioids

Exclusion Criteria:

• Presence of psychiatric comorbidity

• Presence of chronic pain disorder

• Presence or history of substance use disorder

• Current analgesic or neuroleptic medication usage (any medication for pain, including over-the-counter analgesics like ibuprofen/acetaminophen)

• Pregnancy

• Positive drug urine test

• Continuous opioid misuse measure score of < 9

• Presence or history of diabetes

• Presence or history of cardiac disease or arrhythmia