Reduction Bleeding in Laminectomy With Double Doses of Tranexamic Acid

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Tranexamic acid has benn widely used to reduce perioperative bleeding in several operations such as cardiac surgery, liver transplant and joint arthroplasty with good results. Few studies in laminectomy had conflicting results and varying in doses. The objective is to compare perioperative bleeding in major laminectomy between patients receive doubles doses of tranexamic acids (15 mg/kg and 15 mg/kg) with who receive pacebo (0.9% NaCl).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Tranexamic Acid; Tranylcypromine

Criteria

Inclusion Criteria:

• has laminectomy with instrumentation or equal or more than 3 levels laminectomy

• age 18-65 years

• ASA 1-3

• elective operation

Exclusion Criteria:

• allergy to tranexamic acid

• anemia (Hb<12 g/dl in female or Hb<13 g/dl in male)

• history of CVT, IHD, PE, strokes

• liver disease

• chronic kidney disease with creatinie>2.0 mg/dl

• receive anticoagulant or coagulopathy