Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial

• Status: Not yet recruiting
• Trial end date: 2023-02-28
• Target enrollment: 0
• Participant gender: Female

Summary

The overarching objective of this research is to generate clinical evidence to argue the benefits of long acting stimulation protocol compared to the daily stimulation protocol in poor ovarian responder bologna' criteria patients after controlled ovarian stimulation. Reduction in the proportion of subjects with progesterone > 1.1 ng/ml on the day of triggering (day + 13) in the experimental group compared to the control group is expected.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS San Raffaele
• Treatments: Follicle Stimulating Hormone

Criteria

Inclusion Criteria:

• Indication to IVF treatment

• Normal BMI (18.5-24.9 kg/m2)

• AMH level < 1.1 ng/ml and/or AFC < 5 follicles and/or < 3 oo-cytes retrieved in previous cycle

• Regular menstrual cycles

• Signed informed consent

Exclusion Criteria:

• Freeze all cycles for abnormal bleeding

• PCOS

• History of untreated autoimmune

• Endocrine or metabolic disorders

• Ovarian cystectomy or oophorectomy

• FSH ≥ 20 lU/L