Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences

• Status: Completed
• Trial end date: 2021-04-12
• Target enrollment: 0
• Participant gender: All

Summary

The overall goal of this project is to better understand the effect of intermittent hypoxia (IH) on sympathetic neuronal discharge patterns in humans, as well as mechanisms that mediate persistent sympathoexcitation with IH.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia
• Collaborators: Mayo Clinic; National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Bosentan

Criteria

Inclusion Criteria:

• healthy adult men and women;

• 18-45 years of age;

• BMI <30 kg/m2;

• non-pregnant/non-breastfeeding;

• non-smokers.

Exclusion Criteria:

Subjects will be excluded if they are:

• taking any medications known to affect the cardiovascular or autonomic nervous system (e.g. alpha-blockers, beta-blockers, etc);

• Apnea Hypopnea Index >10 events/hr

Self-reported history of:

• hepatic, renal, pulmonary, cardiovascular, or neurological disease;

• stroke or neurovascular disease;

• bleeding/clotting disorders;

• sleep apnea or other sleep disorders;

• diabetes;

• smoking;

• history of alcoholism or substance abuse;

• hypertension.