Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots
Status:
Active, not recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
This multi-center exploratory clinical trial is a randomized trial designed to test whether a
regenerative endodontic procedure using tissue engineering principles (REGENDO), or a
revascularization (REVASC) endodontic procedure, in comparison to standard apexification
treatment using a mineral trioxide aggregate barrier (apexification; APEX), produces a
significantly better composite clinical outcome for the treatment of immature permanent teeth
with pulpal necrosis.
Phase:
Phase 1
Details
Lead Sponsor:
Kenneth Hargreaves
Collaborators:
American Association of Endodontists Loma Linda University University of Maryland University of Maryland, College Park University of North Carolina
Treatments:
Anti-Bacterial Agents Antibiotics, Antitubercular Bacitracin Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination Ciprofloxacin Metronidazole Minocycline Neomycin Polymyxin B