Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Alfentanil (Alf) is used in combination with Propofol (Pro) in fiber-bronchoscopy and in many
other conscious sedation procedures. Alf and Pro have the characteristic of rapid anesthetic
onset and quick recovery, synergic sedative effect and unwanted side effects too. However,
the amount of Alf needed in combination with Pro for induction and the timing of
administration was no standardized. The investigators designed this study to evaluate the
optimal regimen, dose and timing of Alf in Target-Controlled infusion (TCI) of Pro for
flexible bronchoscopy sedation, and also to evaluate the influence of variable regimen of Alf
and Pro on hypoxemia, hypotension, cough severity, and Pro injection related pain.