Regional Anaesthesia and Substance P in Head and Neck Cancer

• Status: Unknown status
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: All

Summary

In the clinical trial the investigators will observe the impact of regional anesthesia in addition to a general anesthesia on the expression of substance P in patients with unilateral Head or Neck cancer undergoing unilateral Neck Dissection. The investigators will perform an unilateral regional cervical plexus block on the tumor side. The tissue of the tumor side will be analysed by immunohistology, measuring the expression of the Substance P.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Charite University, Berlin, Germany
• Treatments: Anesthetics; Neurokinin A; Substance P

Criteria

Inclusion Criteria:

• Patients at Charité - Universitaetsmedizin Berlin, Campus Charité Mitte

• Primary diagnosis of unilateral head or neck cancer

• Resection of Tumor is planned with unilateral neck dissection

• Patient did not underwent any therapeutic treatment of the cancer before start of study

• Surgical therapy is planned with curative intent

Exclusion Criteria:

• Allergy to local anesthetics

• Coagulation disorders, which can lead to complications in regional anesthesia

• Insulin-dependent diabetes mellitus, polyneuropathy

• Severe psychiatric disorders

• Dementia

• Alcohol abuse, Korsakoff syndrome

• Medication with immunosuppressants or immune modulantia

• Patient under Special Care

• Refusal of study participation

• Pregnancy and breast feeding period.

• Participation in a clinical intervention study, parallel with the study or participation up to 30 days before inclusion

• Lack of consent that pseudonomized data of the study may be saved and distributed