Regional Cryotherapy in Preventing Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
Status:
Unknown status
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The trial will be preceded by a pilot phase study in 5 patients.
This will then be followed by the randomized 1:1 phase II trial testing the utility of
regional cryotherapy in preventing or reducing paclitaxel-induced peripheral neuropathy
compared to no treatment.
It is hypothesized that cryotherapy causes regional blood vessel constriction and decreases
the paclitaxel exposure to the distal epithelial nerve fibres, thus resulting in decreased
nerve damage.
Phase:
Phase 2
Details
Lead Sponsor:
National Cancer Centre, Singapore
Collaborators:
Duke-NUS Academic Medicine Research Institute Singapore General Hospital Terry Fox Foundation