Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
Status:
Completed
Trial end date:
2019-01-17
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether or not giving a lower dose of antibiotics
(Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining
adequate tissue levels of the antibiotic than the current standard dose which is given
intravenously (IV) through a wrist vein. The use of intraosseous regional administration
(IORA) of vancomycin requires the use of a tourniquet for the duration of the procedure. Many
surgeons prefer to perform the surgery with tourniquet use minimised or without a tourniquet
at all. The aim of this study is to evaluate whether IORA vancomycin can achieve effective
tissue concentrations with tourniquet use minimised.