Registration of the Study of Reyanning Mixture

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the efficacy and safety of treating with acute tonsillitis using Reyanning mixture alone/in combination with antibiotics, and its function of reducing the use of antibiotics.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: China Academy of Chinese Medical Sciences
• Collaborators: Beijing Chao Yang Hospital; Beijing First Hospital of integrated Chinese and Western Medicine; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine; Wangjing Hospital, China Academy of Chinese Medical Sciences
• Treatments: Amoxicillin

Criteria

Inclusion Criteria:

1. Meet the diagnostic criteria of acute tonsillitis;

2. Meet the traditional Chinese medicine symptom diagnostic criteria of external wind-heat type and excessive heat in the lung and stomach type;

3. 18 years≤age≤65 years;

4. course of disease within 72 hours;

5. sign informed consent.

Exclusion Criteria:

1. common cold,influenza, acute laryngopharyngitis, pharyngeal diphtheria, wensang's isthmitis.

2. complicated with acute tracheobronchitis,pneumonia,rheumatic fever, acute glomerulonephritis or rheumatic heart disease.

3. complicated with severe angiocardiopathy, cerebrovascular disease, hemopoietic system disease or psychopath.

4. liver or kidney function is abnormal(ALT>1.5 times upper limit of normal; Cr>upper limit of normal); diabetic.

5. WBC<10×109/L and neutrophilic granulocyte percentage<75%;or WBC ≥20×109/L;

6. gestational, lactating women or who planning to get pregnant within half a year.

7. already accept similar traditional Chinese medicine or antibiotic within 48 hours before registered.

8. joining other clinical trials or allergic to any drug in this trials.