Registry for Estimation of Warfarin and Rivaroxaban in Atrial Fibrillation Patients With Coronary Stent Implantation

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting. Similarly, anticoagulant therapy is essential for the prevention of cardiogenic embolism including cerebral infarction in AF patients. However, the combined antithrombotic therapy has been reported to increase the risk of major bleeding for AF patients after coronary stenting, New anticoagulant drugs that hardly interact with other drugs and do not need frequent blood tests have become commonly used. The purpose of this study is to assess the hypothesis that Rivaroxaban is non-inferior to Warfarin in the efficacy and safety for AF patients after coronary stenting.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fujita Health University
• Collaborator: Bayer Yakuhin, Ltd.
• Treatments: Rivaroxaban; Warfarin

Criteria

Inclusion Criteria:

• Clinically stable atrial fibrillation (AF) patients who underwent coronary artery stenting more than one year ago and are treated or are scheduled to be treated with anticoagulant drug (regardless of the type of stents and AF).

• Those who are willing to cooperate with us in the study

• Those who can sign the informed consent document that is approved by the ethics committee of the medical institution participating in the study

Exclusion Criteria:

• Those in whom the package inserts state anticoagulant drugs are contraindicated for use

• Those who are scheduled to undergo percutaneous coronary intervention or catheter ablation for AF

• Those who have to continuously undergo dual antiplatelet due to a past history of stent thrombosis during the distant stage after stenting

• Those who have undergone prosthetic valve replacement for valvular disease

• Those who the physician in charge judges are ineligible for the study due to serious pathological conditions

• Those who are not willing to participate in the study