Regulation of Bone Formation in Renal Osteodystrophy

• Status: Completed
• Trial end date: 2006-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To examine the effects of two types of active vitamin D (calcitriol and doxercalciferol) and two phosphate binders (sevelamer and calcium carbonate) on the bone disease and blood tests of children with kidney failure

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: 1 alpha-hydroxyergocalciferol; Calcitriol; Calcium; Calcium Carbonate; Calcium, Dietary; Cholecalciferol; Dihydroxycholecalciferols; Ergocalciferols; Sevelamer; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Stable end-stage kidney disease treated with continuous cycling peritoneal dialysis,

• Biochemical evidence of secondary hyperparathyroidism (PTH>400 pg/ml) with bone biopsy evidence of high turnover bone disease

Exclusion Criteria:

• History of parathyroidectomy

• Growth hormone

• Prednisone, or other immunosuppressant medication within the past year.

• Recent history of medication non-compliance.