Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
It is well known that the hormone insulin lowers blood glucose in part by acting directly on
the liver and reducing hepatic glucose production. Animal studies have shown that the hormone
insulin can act on the brain to indirectly lower glucose production by the liver. It has
previously been shown that a nasal spray can deliver insulin directly to the brain without
affecting circulating insulin concentration in humans. Intranasal spray of insulin suppressed
hepatic glucose production in lean subjects. It is unknown whether this effects is blunted in
subjects with insulin resistance.