Regulation of Endogenous Glucose Production by Central KATP Channels
Status:
Recruiting
Trial end date:
2027-04-30
Target enrollment:
Participant gender:
Summary
Type 2 diabetes affects the ability of the body to process glucose (sugar). Under fasting
conditions, the liver is able to make sugar to maintain glucose levels in an important
process called endogenous glucose production (EGP). Previous studies suggest that the central
nervous system (CNS), including the brain, helps to regulate levels of glucose in the body by
communicating with the liver. This process can be impaired in people with type 2 diabetes,
and can contribute to the high level of glucose seen in these individuals.
The purpose of this study is to understand how activating control centers of the brain with a
medication called diazoxide can affect how much glucose (sugar) is made by the liver. This is
particularly important for people with diabetes who have very high production of glucose,
which in turn can lead to diabetes complications.
Phase:
Phase 2
Details
Lead Sponsor:
Albert Einstein College of Medicine Albert Einstein College of Medicine, Inc.
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH)