Regulation of Intestinal and Hepatic Lipoprotein Secretion by Resveratrol
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
Resveratrol, an ingredient of red wine and available in Canada in highly purified form as an
over-the-counter health supplement, has been shown to have a number of health benefits. Data
from in vitro and animal studies suggest that it has beneficial effects on insulin
sensitivity and lipid lowering. The investigators are not aware, however, of any mechanistic
studies that have examined the effect of highly purified resveratrol in vivo on lipoprotein
metabolism in humans. Given the potential therapeutic benefit of resveratrol in correcting
the metabolic abnormalities of insulin resistant individuals the investigators plan to
examine the effects of resveratrol on intestinal and hepatic lipoprotein production in
humans.