Regulatory Lymphocytes in Patients Treated With Specific Immunotherapy

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether specific subcutaneous immunotherapy affects fractions of regulatory T lymphocytes and histamine H2 receptor expression and ZAP70 in regulatory T lymphocytes.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ministry of Science and Higher Education, Poland

Criteria

Inclusion Criteria:

• seasonal allergic rhinitis with or without allergic conjunctivitis

• sensitization to grass pollen allergens (confirmed with skin prick tests, conjunctival provocation test, specific IgE)

• symptoms of allergic rhinitis with or without conjunctivitis for at least 2 years before the study

Exclusion Criteria:

• sensitization to allergens, that could interfere with grass pollen

• asthma

• cystic fibrosis

• ciliary dysmotility syndrome

• bronchiectasis

• smoking

• tuberculosis

• neoplastic disease

• chronic sinusitis and nasal polyps

• systemic glucocorticosteroids treatment

• treatment with immunotherapy in the past