Relationship Between Efficacy of Lumateperone and Brain Glutamate and Dopamine
Status:
Recruiting
Trial end date:
2026-06-01
Target enrollment:
Participant gender:
Summary
This study will examine the differential relationships between antipsychotic efficacy and
changes in dopaminergic and glutamatergic brain metabolism in lumateperone and risperidone
treated early psychosis patients. Baseline glutamate and dopamine brain scans, and symptom
severity measures will be collected, followed by repeated measures at 6 weeks. Half of the
early psychosis patients will be treated with lumateperone, half with risperidone. Healthy
control subejcts will also be examined once.