Relationship Between Folic Acid and Warfarin Metabolism and Effect
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Folic acid supplementation has been shown previously to be associated with enhanced formation
of p-HPPH from phenytoin, a metabolic pathway which is predominantly mediated through the
activity of CYP2C9.
The metabolism of S warfarin, the more active enantiomer of warfarin, is also mediated
predominantly through the activity of CYP2C9.
The purpose of the present study was to examine the relationship between folic acid
concentration and warfarin pharmacokinetic as well as warfarin dose requirement among
patients treated by warfarin. In addition the effect of folic acid supplementation (5 mg/d)
for 3 weeks on warfarin pharmacokinetic and warfarin dose requirement will be evaluated in
the second part of the study.