Relationship Between HIV and Malaria in Ugandan Children

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

HIV and malaria are two of the most important diseases to afflict children in sub-Saharan Africa. However, it is unknown what relationships exist between the two diseases. The purpose of this study is to determine the relationship between HIV and malaria infections in HIV infected Ugandan children.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Amodiaquine; Artesunate

Criteria

Inclusion Criteria:

• HIV infected

• Resides within a 20 km (12.4 mi) radius of the study clinic in Kampala, Uganda

• Had a minimum of 1 regularly scheduled clinic visit in the 3 months prior to study entry

• Willing to return to the study clinic if fever or other illness occurs during this study

• Willing to avoid medications administered outside the Mulago Hospital Complex

• Parent or guardian willing to provide informed consent

Exclusion Criteria:

• Intends to move more than 20 km (12.4 mi) from the study clinic during the follow-up period

• Weigh less than 5 kg (11 lbs)

• Participating in another Infectious Disease Clinic (IDC) cohort study

• Any current medical problem requiring in-patient evaluation or home care

• History of allergy or sensitivity to amodiaquine, artesunate, or quinine

• Life-threatening screening laboratory values in the absence of malaria. More information on this criterion can be found in the protocol.