Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)

• Status: Recruiting
• Trial end date: 2024-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The intravenous injection of lidocaine during the perioperative period has been widely used in various types of surgeries. Its clinical effect includes reducing stress response during anesthesia, decreasing pain and opioid consumption, lowering the incidence of postoperative nausea, vomiting, cognitive dysfunction, and reducing the injection pain of propofol. However, despite the positive impact of lidocaine on surgical patients, its mechanism of action remains unclear. Serum N/OFQ is a neurotransmitter that plays an important role in regulating pain and emotion. Therefore, this study aims to explore the effects of perioperative intravenous injection of lidocaine on stress responses in surgical patients, as well as its mechanism of action, and whether Serum N/OFQ participates in this process.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Hospital of Shanxi Medical University
• Treatments: Dsuvia; Etomidate; Lidocaine; Propofol; Remifentanil; Rocuronium; Sufentanil

Criteria

Inclusion Criteria:

• ASA I-II

• Patients undergoing elective abdominal surgery with anesthesia duration less than 1-2h

Exclusion Criteria:

• It is estimated that patients with difficulty in tracheal intubation (poor head and neck mobility, history of airway surgery, history of OSAHS, nail to chin distance<6cm, Malampati grade 3 and above, mouth opening<2.5cm, obesity (BMI>30kg · m-2), etc.)

• Hypertension patients (clinically diagnosed as hypertension), coronary heart disease patients (with typical symptoms of angina pectoris and exclusion of aortic valve disease, clear history of old myocardial infarction, clear history of acute myocardial infarction)

• Patients with diabetes and central nervous system diseases

• Patients with long-term use of sedatives or antidepressants

• Patients with a history of alcoholism or drug dependence

• Asthma or reactive airway disease

• Shock, severe hypotension, severe arrhythmia and other adverse events occurred during the operation