Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)
Status:
Recruiting
Trial end date:
2024-07-31
Target enrollment:
Participant gender:
Summary
The intravenous injection of lidocaine during the perioperative period has been widely used
in various types of surgeries. Its clinical effect includes reducing stress response during
anesthesia, decreasing pain and opioid consumption, lowering the incidence of postoperative
nausea, vomiting, cognitive dysfunction, and reducing the injection pain of propofol.
However, despite the positive impact of lidocaine on surgical patients, its mechanism of
action remains unclear. Serum N/OFQ is a neurotransmitter that plays an important role in
regulating pain and emotion. Therefore, this study aims to explore the effects of
perioperative intravenous injection of lidocaine on stress responses in surgical patients, as
well as its mechanism of action, and whether Serum N/OFQ participates in this process.