Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery
Status:
Completed
Trial end date:
2022-09-30
Target enrollment:
Participant gender:
Summary
Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery,
mainly manifested as mental confusion, anxiety, personality change and memory impairment,
which seriously affects the quality of life of patients after surgery.Attention should be
paid to the protection of neurological function in patients undergoing cardiac surgery during
perioperative period.Nicardipine can selectively act on coronary arteries and cerebral
vessels, increase coronary artery and cerebral blood flow, relieve coronary heart disease
angina pectoris, protect brain tissue.The cerebral protective effect of nicardipine on
cardiovascular surgery under CPB deserves further clinical study.About 15-20% of cardiac
output (CO) in healthy adults is allocated to the brain , and cerebral blood flow is supplied
by bilateral internal carotid artery (ICA) and vertebral artery (VA), among which ICA
provides about 70%-80% of cerebral perfusion flow .However, the location of the internal
carotid artery is superficial, the anatomical variation is less, and the ultrasonic Doppler
technique is portable and simple to measure. It may be of certain clinical value to use the
ultrasonic detection technology to quickly evaluate the cerebral perfusion during the
perioperative period, and to early detect and avoid the intraoperative brain function injury.
Phase:
N/A
Details
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University