Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Our overall hypothesis is that treatment of periodontal disease will produce better diabetes
glycemic control (glycated hemoglobin A1c, or HbA1c) and reduced levels of the catalytically
active form of matrix metalloproteinase (aMMP-8) in the Gullah African American type 2
diabetes patients living on the Sea Islands of the South Carolina coast. The gingival
crevicular fluid (GCF) aMMP-8 levels will be measured through a site-specific, novel
noninvasive technique allowing the pathophysiological status of the periodontium tissue to be
monitored. The investigators will conduct an interventional study on this population with
minimal genetic admixture.