Release of Osteogenic Markers in Immediately and Non-loaded Dental Implants
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study was to compare the release of the osteoprotegerin (OPG), transforming
growth factors (TGF-α), osteocalcin (OCN), osteopontin (OPN), and parathyroid hormone (PTH)
during osseointegration of dental implants with and without immediate loading. Forty patients
were selected and randomly divided into: Group IM - implant and prosthesis placement within
72 hours; and Group NL - implant insertion and no prosthesis placement during 120 days.
Peri-implant crevicular fluid (PICF) was collected immediately after implant insertion and
with 7, 15, 30, 60, 90, and 120 days after surgery and were evaluated levels of OPG, TGF-α,
OCN, OPN and PTH using Luminex assay. Clinical aspects (Sulcus bleeding and peri-implant
probing depth) were also assessed. The data were compared using the ANOVA/Tukey and
Friedman/Mann-Whitney tests (α=5%).