Remifentanil Use in Pediatric Rigid Bronchoscopy

• Status: Completed
• Trial end date: 2006-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose: In this study we wanted to compare bolus propofol and ketamine as an adjuvant to remifentanil-based total intravenous anesthesia for pediatric rigid bronchoscopy.

Materials and Methods: Forty children under 12 years of age scheduled for rigid bronchoscopy were included. After midazolam premedication, remifentanil infusion 1 µg/kg/min was started and patients were randomly allocated to receive either propofol (Group P) or ketamine (Group K) and mivacurium for muscle relaxation. Anesthesia was maintained with remifentanil infusion 1 µg/kg/min and bolus doses of propofol or ketamine. After rigid bronchoscopy remifentanil 0.05 µg/kg/min was maintained until extubation. Hemodynamic parameters, emergence characteristics and adverse events were evaluated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bezmialem Vakif University
• Treatments: Ketamine; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• Children who were scheduled to have rigid bronchoscopy for diagnostic purposes (suspected foreign body aspiration, bronchoalveolar lavage)

• Children who were scheduled to have rigid bronchoscopy for therapeutic purposes (removal of foreign bodies and/or mucus plugs)

Exclusion Criteria:

• Severe cardiovascular disease

• Cerebral, hepatic or renal dysfunction

• Neuromuscular disease

• Children with predicted difficulty in laryngoscopy and intubation

• Patients requiring prompt interventions for a life-threatening situation (acutely compromised airway with SpO2 values below 70%)

• Patients scheduled for additional interventions or surgery subsequent to rigid bronchoscopy