Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will investigate the influence of intra-operative use of remifentanil versus fentanyl on the percentage of patients with chronic thoracic after cardiac surgery via sternotomy. Secondary quantitative sensory testing is performed to determine thermal and electrical detection and pain threshold and the difference in pain variability scoring. Postoperative pain scores, analgesic use, genetic variances and costs are measured.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Antonius Hospital
• Treatments: Fentanyl; Remifentanil

Criteria

Inclusion Criteria:

• Patients undergoing cardiac surgery via sternotomy (Coronary artery bypass graft (CABG) and/or valve replacement)

• Patients admitted to the ICU or PACU in the St. Antonius hospital

• Patients between 18 and 85 years old

• Patients weighing between 45 and 140 kg

• Written informed consent

Exclusion Criteria:

• Pregnancy/ breastfeeding

• Language barrier

• History of drug abuse

• Neurologic condition such as peripheral neuropathy

• Known remifentanil, fentanyl, morphine or paracetamol allergy

• Body Mass Index (BMI) > 35 kg/m2

• Prior cardiac surgery (re-operations);

• Patients with chronic pain conditions.