Removal of Beta Blocker Drugs by Hemodialysis

• Status: Completed
• Trial end date: 2016-03-10
• Target enrollment: 0
• Participant gender: All

Summary

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Treatments: Adrenergic beta-Antagonists; Bisoprolol

Criteria

Inclusion Criteria:

• at least 18 years of age, receiving hemodialysis three times per week for at least 90 days.

Exclusion Criteria:

• gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).